- Goddess, Adam Warlock's "Good Side", recruits an army of heroes to fight her holy war. Thanos and Adam Warlock unite to stop her. (Infinity Crusade)
- On Mojoworld, Dazzler miscarries her and Longshot's baby.
- The Carnage Family massacres downtown New York only to have Spider-Man and Venom in their way. (Maximum Carnage)
- Illyana Rasputin succumbs to the Legacy Virus.
- Magneto returns more powerful and determined than ever, ripping the adamantium from Wolverine's bones and enraging Professor X. Colossus defects to Magneto's side. (Fatal Attractions)
- Another batch of X-Babies shows up on Earth. They are on the run from Gog and Magog. Dazzler appears to offer them a safe place to stay with her and Longshot.
- The Phalanx race attacks Earth. Generation X is founded in its aftermath. (Phalanx Covenant)
- [October 8] Marcelo Joaquim Alencar da Silva is born in Brazil to Letícia Marisa Alencar da Silva and Luíz Adriano Alencar da Silva.
- The clone of Spider-Man, who was long thought dead, returns. His creator, the Jackal, also returns to wreak havoc in Spider-Man's personal life. (Clone Saga)
- Legion travels back in time to kill Magneto, but accidentally kills his own father, Charles Xavier, creating a dystopian alternative timeline in which Apocalypse rules the world.
- The Fantastic Four and others battle against forces who are literally raising the city of Atlantis from the depths of the ocean. (Atlantis Rising)
- [July 15] Mikhail Loganovich is born to Natasha Romanova and Logan.
- [September 1] Susan Barton is born to Bobbi Morse and Clint Barton
- [January 15] Samantha Fury is born to La Contessa Valentina Allegra de la Fontaine and Nick Fury
- [February 2] Nicky Blake is born to Sif and Thor
- [May 22] Luna Maximoff is born to Crystalia Amaquelin and Pietro Maximoff
- [June 4] Harada Takeshi is born to Yukio and Harada Keniuchio
- [July 4] Yukio drops off her month-old son, Takeshi, to be full-time in his father’s care
- [July 15] Marcus Whitman is born to Sersi and Dane Whitman in the 12th century
- [October 6] Sofia Strange is born to Clea and Stephen Strange
- Ares joins the Avengers
- [February] As they are coming back from the 12th Century, Sersi gets separated from Dane Whitman and their son. It is unknown what happened to her.
- A refugee from Mojoworld named Windsong arrives on Earth and moves in with the Guthrie family
- Manuel de la Rocha meets and starts manipulating Regan Wyngarde
- [May] Longshot and Dazzler return to Earth after defeating Mojo II: The Sequel. They end up in Japan where Longshot joins up with a clan of mostly female ninjas who regularly clash with the Hand.
- [May] Dane Whitman dies from cancer
- [August 31] Angela Wagner is born to Rogue and Kurt Wagner
- [September] Due to a spell cast by Amora, Carol Danvers sleeps with Ares and conceives a child.
- Sara Summers is born to Jean Grey-Summers and Scott Summers
- [January 1] Aiden and Hana Blaire are born to Alison Blaire and Longshot
- Caroline Song is born to Windsong
- [May 4] Roxie Danvers is born to Carol Danvers and Ares
- [July 17] Jennifer Walters marries Wyatt Wingfoot
- [August 17] Bruce Jones is born to Marlo Chandler-Jones and Rick Jones
- [October 7] Brooke Wyngarde is born to Manuel de la Rocha and Regan Wyngarde
- [April 1] Mary Storm is born to Lyja and Johnny Storm
- [April 13] Jay Jonathan Walters-Wingfoot is born to Jennifer Walters and Wyatt Wingfoot
- [September 3] Jesse Hunt is born to Jessica Drew and Jerry Hunt
- Rose Knight-Rand is born to Misty Knight and Danny Rand
- [June 29] Peter Eastman is born in Kansas City, Mo.
- [August 12] Rose Logan is born to Birdy and Victor Creed
- Liza Hellstrom is born to Patsy Walker and Damion Hellstrom
- David Roberts is born to Catherine Roberts and Logan
- [July] She-Hulk gets pulled on to an extended space mission with her son in tow. They are gone long enough that Jay misses starting school.
- [November 14] Letícia Marisa Alencar da Silva is killed as her chauffeured car makes a wrong turn and ends up in the middle of a gunfight between rival gangs. Her last act was to cover her young son, Marcelo, from the bullets.
- Lena Essex emerges from a vat full grown for her father, Mr. Sinister
- Reed and Susan Richards are lost and presumed dead after a massive explosion on a mission in another dimension.
- Audhild Amoradottir is born to Amora and Victor Doom
- The Silver Samurai loses the leadership of Clan Yashida to the Mongolian crimelord Haan Kaishek. Despite defeating Kaishek later, Kenuichio's honor would not be restored as the win was said to be more Wolverine's work than the Silver Samurai's.
- [October 20] Emily Rose Hudson is born to Kristen Hudson and Logan
- David Roberts meets Logan for the first time. After David’s mother’s health improves, she agrees to share custody of her son with Logan.
- The Silver Samurai falls under the employ of the Hand and is sent to kill the wayward Elektra. Kenuichio is killed during the confrontation.
- [February 11] Sif dies and Nicky Blake is exiled to Midgard.
- [October] Reed Richards is rescued from a time status bubble in another dimension by the Imaginauts.
- [December] Susan Richards is rescued from a Unseelie-infested dimension by the Fantastic Four and Imaginauts.